Chiral Auxiliaries in Asymmetric Synthesis

Background The use of chiral auxiliaries in the synthesis of enantiomerically pure compounds has found wide application for a variety of reactions over the last three decades. Despite the extensive developments in this area by many academic and industrial research groups, new auxiliary controlled reactions continue to evolve frequently [1]. First objectives in this area have been to develop chiral enolate-derived reactions, wherein the chiral auxiliary (Xc) is both readily available and easily recovered after the desired bond construction has been achieved (Scheme 1).